(This isn't an actual spoiler, it's just discussing something that DID happen in the book, and something I hope WON'T happen in the book.) Life extensions, since the MC is only supposed to have a few years to live, and that would take away the pressure from the story.
He escapes of course
especially after seeing his Determinator/Superpowered ultra focused state from chapters 28-31
ability to have unlimited devil fruit powers
Yandere non-blood-related imouto, a yuri loli, 2 tsundere lolis, one of whom is a princess, and the other a transported person like MC, a mechanical loli (she is a shikigami, that gained its own consciousness, in the form of a loli)... that's most/all I think...